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Ibuprofen side effects long term liver2/11/2024 Ibuprofen elevated activity of cytochrome P450, which breaks down drugs, in females but decreased it in males. For example, the proteasome - a waste-disposal system that removes unwanted proteins - responded differently in males and females. The researchers found that ibuprofen had different, and in some cases opposite, effects in the livers of male and female mice. Different effects in male and female mice Hydrogen peroxide damages proteins and stresses liver cells. They included pathways involved in metabolism of amino acids, hormones and vitamins as well as production of reactive oxygen and hydrogen peroxide inside cells. “We found that ibuprofen caused many more protein expression changes in the liver than we expected,” Gomes said.Īt least 34 different metabolic pathways were altered in male mice treated with ibuprofen. Then they used advanced mass spectrometry at UC Davis’ Proteomics Core Facility to capture information on all the metabolic pathways in liver cells. Gomes, postdoctoral researcher Shuchita Tiwari and colleagues dosed mice with a moderate amount of ibuprofen for a week - equivalent to an adult human taking about 400 mg of the drug daily. It’s well-established that ibuprofen can cause heart problems and increase stroke risk, but the effects on the liver were less well understood, said Professor Aldrin Gomes, Department of Neurobiology, Physiology and Behavior in the UC Davis College of Biological Sciences. Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs, widely used over the counter to treat pain and fever. The study in laboratory mice also shows marked differences between males and females. The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from the University of California, Davis.
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